The Chapel at Palmetto Bluff is a culmination of design elements and materials that were essential in the creation/recreation of an iconic symbol seen in small towns and communities for centuries across the South. The primary influence of the simple, wood-clad structure was a small church on Edisto Island, which had a deep porch across the front, providing refuge from the elements.

The materials are those typically used a century ago, such as the wide board pine floors made from 1,250 square feet of Long Leaf Heart Pine reclaimed from the Piedmont Mill in Piedmont, SC. The Chapel Pews were handcrafted from 3,000 pounds of refurbished Antique Heart Pine, which was recovered from a New York City building destroyed on September 11, 2001. The high gothic triple-hung windows were important not only to the look, but particularly to the function of the space, as they rise from the floor six feet to allow easy passage from indoors to the lawn outside.

Bricks used for the Chapel came from the Old Carolina Brick Company, and were hand molded on the colonial tradition of craftsmanship and lasting beauty. The steeple bell was rung for the first time on September 1, 2004. Genesis Construction commissioned the Chapel Bell to be handcrafted by The Verdin Company of Cincinnati, Ohio. Verdin is a fourth-generation Bellforge established in 1842.